Familial cerebral cavernous malformation (FCCM), prevention and healing renovation:

Since my stroke I’ve been determined to research about how a genetic cavernous malformation, or cavernoma (CCM) carrier and those presenting symptoms from a hemorrhage can optimize their life for prevention and healing renovation. I personally carry the CCM1 mutation which lead to hemorrhages in my brainstem and cerebellum resulting in a resection surgery. This research goes well beyond a low inflammatory lifestyle which is Important but, in my option, our light environment is much more important. Ideally diet, exercise, a low stress environment and light are together the recipe for success. I’ll be focused on our light environment – the greatest reward ratio will be combining all. Just to be clear I’m not a Dr. and my findings are of my own research and anecdotal evidence (personal experience). This article covers the importance of early AM sun light, grounding and their role in renovating our bodies from the harmful effects of artificial light, non-native electromagnetic frequencies (nnEMF) and environmental factors. You may be asking what do those have to do with CCM. Overall health and wellbeing are all relative, and anything harmful directly to the brain is even more important for a person with a neurological disease.

The two forms of CCM:

There are familial and sporadic forms of the disease. According to The National Institute of Neurological Disorders and Stroke, “They can happen on their own (sporadic) or run in families (this is called familial CCM). Most people with CCMs have the sporadic type, which means no one else in the family has the disorder.”¹ The familial form is passed from parent to child as a genetic mutation, and those persons typically develop multiple cerebral cavernous malformations. The sporadic form occurs in people with no prior family history and typically only develop one malformation. The Alliance To Cure Cavernous Malformation acknowledges,

Genes are packaged in chromosome pairs. We all have two copies of every gene in our genome, with one inherited from each parent. Germline mutations are those that are inherited from a parent, and therefore present in every cell of the body. By contrast, somatic mutations (italics added) are randomly acquired over time and not present in all cells.²

CCM genetic mutation types:

Since 1999, there have been three genes identified as a cause for the familial form of CCM. On the Alliance To Cure Cavernous Malformation website it states,

CCM1 is responsible for creating the CCM1 protein, also called KRIT1, or Krev interaction-trapped 1 protein. The second gene is called CCM2 and controls the production of a protein named malcavernin. The third gene, CCM3, is responsible for creating a protein called Programmed Cell Death 10 or PDCD10. The name of the protein refers to this gene’s function in regulating cell survival.

Research has uncovered that these three gene products (proteins) each have their own unique properties, and also work together as part of a signaling complex, communicating and interacting with each other. The signaling complex is related to critical processes, such as maintaining the tight junctions between neighboring blood vessel cells, cell cycle regulation, and blood vessel development.³

These mutations are what cause FCCM, the specific functions that these genes play a role in are not completely understood yet, however we have a good underpinning of the broad purpose they have together. According to the US Government site, MedlinePlus,

The proteins interact with each other as part of a complex that strengthens the interactions between cells and limits leakage from the blood vessels. Mutations in any of the three genes impair the function of the protein complex, resulting in weakened cell-to-cell junctions and increased leakage from vessels as seen in cerebral cavernous malformations.⁴

“Two-hit mechanism”:

The “two-hit mechanism” refers to a genetic model, originally described for tumor suppressor genes, where both alleles of a gene must be inactivated for a disease phenotype to manifest. This mechanism is analogous to Knudson’s two-hit hypothesis for tumor suppressorsformulated in 1971, as evidenced in a 2021 article in The American Society for Cell Biology.⁵In the context of CCMs, this means that for a lesion to form, both copies of CCM1, CCM2, or CCM3 gene in the affected endothelial cells must be mutated, typically through a combination of a germline mutation (inherited) and a somatic mutation (acquired during life). See Figure 1 for a “two-hit mechanism” visual.

Figure1. “Two-Hit Mechanism”⁶

According to an article in the American Heart Association Journal, “Most familial CCMs are nonsense, frameshift, and canonical splice-site mutations”⁷, these loss of function mutations cause premature stop codons according to Madame Curie Bioscience Database ⁸. A premature stop codon is a mutation in DNA that introduces an early stop signal, leading to a shortened, often nonfunctional protein. Many genetic diseases are caused by premature stop codons showing us the effects of a premature termination as evidenced from an article in The Journal Biological Chemistry.⁹

Research suggests that for CCM1, CCM2, and CCM3 mutations to create lesions, a two-hit mechanism is likely needed. This means both copies of the gene must be damaged. Usually, one mutation is inherited (germline), and the other happens later in life (somatic) in the affected blood vessel cells. This double hit is probable for the lesions to form, especially in familial cases where multiple lesions are common. This mechanism helps explain why some people with a CCM mutation don’t develop lesions until later in life, as the second hit might take time. It’s also why sporadic cases (without family history) often have only one lesion as both hits need to occur by chance in the same cell. While most studies support this, there’s some debate due to challenges in detecting the second mutation, especially in tissue samples. But overall, the evidence leans toward the two-hit model being essential.

This paper published in Human Molecular Genetics in 2008, directly supports the two-hit hypothesis.

Cavernous Familial cerebral cavernous malformations (CCMs) have been associated with germline mutations in CCM1/KRIT1, CCM2 or CCM3/PDCD10. For each of the three CCM genes, we here show complete localized loss of either CCM1, CCM2 or CCM3 protein expression depending on the inherited mutation. Cavernous but not adjacent normal or reactive endothelial cells of known germline mutation carriers displayed immunohistochemical[*] (asterisk added) negativity only for the corresponding CCM protein but not for the two others. In addition to proving loss of function at the protein level, our data are the first to demonstrate endothelial cell mosaicism within cavernous tissues and provide clear pathogenetic evidence that the endothelial cell is the cell of disease origin.¹⁰

It shows us data and evidence that normal or reactive endothelial cells (reactive endothelial cells refers to endothelial cells (the cells lining blood vessels) that have undergone changes in their structure and function in response to various stimuli, such as oxidative stress (caused by reactive oxygen species ROS) and or inflammation)do not cause a loss of function at the protein level, only in the cell with the CCM mutation. This is significant in confirming that there’s a needed presence of the CCM inherited mutation followed by asomatic mutation (second hit) to the cell, to further present a cerebral cavernous malformation lesion.

The two-hit mechanism for a familial CCM involves the following steps:

Step One ® Germline Mutation: In familial cases, individuals inherit a heterozygous mutation in CCM1, CCM2, or CCM3, meaning one allele is already nonfunctional. This mutation is typically a loss-of-function mutation, resulting from “nonsense, frameshift, and canonical splice-site mutations.”⁷

Step Two ® Somatic Mutation: For a lesion to form, a second hit usually from a somatic mutation must occur in the same endothelial cell, inactivating the second allele. This leads to a complete loss of the CCM protein in that cell.

Step Three ® Lesion Formation: The complete loss of CCM protein function disrupts endothelial cell junctions, resulting in the characteristic dilated, leaky capillaries of CCM lesions.

Possible somatic mutation causes and repair processes in place:

When I discovered an individual with a germline mutation like CCM has a mutation in every cell of the body and in order to create a lesion we likely need a second mutation (second hit) in the cell I wanted to protect myself against the possibility of a second mutation. This probing examination led me to research not only the CCM disease but diseases in general. I placed a common denominator across all diseases and found light can be a main component driving harmful damage, more specifically artificial blue light can lead to DNA damage distort the double helix and cause mutations as evidenced in the Journal, Mutation Research.¹¹

The timing of light exposure matters because the body’s DNA damage response (DDR) mechanisms, like nucleotide excision repair (NER), are regulated by circadian rhythms—24-hour cycles driven by our internal clock supported by an article in Nucleic Acids Research Journal.¹² In a 2019 study, scientists found that DNA replication and DNA repair are counter-phased. Most studies of the circadian clock-NER connection have utilized mice for analysis so it’s important to properly apply these findings to humans to improve our full understanding. See Figure 2. for a 24-hour DNA light cycle graphic. For humans its believed NER repair would peak in the morning and slowdown in the evening, where DNA replication activity would peak in the evening and slowdown in the morning. Following the Day-Night cycle of our environment, daylight hours would present the most DNA damage from sunlight supporting the peak of NER in the morning repairing DNA throughout the day before replication begins in the evening.¹³ 

Figure 2. 24-hour DNA light cycle¹³

         From this same study, a new concept “circadian disruption” is being taken serious as an important focus on diseases and human health. This disruption can lead to mutations and drive disease, the study specifically shows how mutations in the DNA are a driver for cancer,

Skin cancer results from the accumulation of mutations in genomic DNA that are generated primarily by UV radiation. If this damage is not efficiently repaired by the nucleotide excision repair (NER) system, or if the damaged cell is not properly redirected to apoptosis, the damaged bases can be replicated by error-prone mechanisms to give rise to mutations that drive the formation of cancer.¹³

Exposure to artificial blue light in the evening can affect your DNA by causing additional damage that your body tries to fix with NER but were no longer in the peak repair phase meaning some DNA may not be repaired correctly. This unrepaired damage can potentially lead to an increase in mutation rates affecting overall cell function and possibly an increase of health issues over time.

Vitamin D plays an important role in helping our cells repair DNA damage, working through a receptor called the calcitriol receptor (VDR.) When DNA is damaged, a protein called Xeroderma pigmentosum, complementation group C (XPC) needs to bind to it and then let go so other repair proteins can fix it. In a 2021 article in the Journal of Investigative Dermatology it reports that VDR helps XPC disengage more efficiently, making the repair process smoother.¹⁴ Without enough Vitamin D this repair may be slower, leading to incomplete or unrepaired damage especially during a period of excess damage. Think of it like Vitamin D is a helper that makes sure our DNA repair team works efficiently.

While grounding doesn’t directly fix DNA, lowering oxidative stress might create a better environment for our body’s natural repair processes to function. The Journal of Inflammation Research hypothesizes,

Earth enables free electrons from the Earth’s surface to spread over and into the body, where they can have antioxidant effects. Specifically, we suggest that mobile electrons create an antioxidant microenvironment around the injury repair field, slowing or preventing reactive oxygen species (ROS) delivered by the oxidative burst from causing “collateral damage” to healthy tissue, and preventing or reducing the formation of the so-called “inflammatory barricade”.¹⁵

This could lower the chance of mutations, including premature stop codons. Oxidative stress happens when free radicals, unstable molecules, damage your cells, including DNA. This damage can lead to mutations, like premature stop codons, which stop protein production early, causing health issues. Grounding may act as an antioxidant by providing electrons, helping neutralize these free radicals and reduce DNA damage.

Neuroplasticity:

Neuroscientists and clinicians alike had a belief that only people younger than 25 had an ability to rewire the brain, but this is now known not to be true. This is now known as neuroplasticity, which is the physical rewiring, repair and reorganizing parts of the brain at any age. This can help chronic pain, trauma healing, emotional regulation of anxiety, depression or heal physical brain damage after injury. By retraining nervous system responses that have become “stuck” in the “fight or flight” mode over time, we can introduce new healthy conditioned responses. 

Neuroplasticity allows us to change and adapt with a few specific mechanisms. In the physical healing of our tissues, we have synaptic plasticity which involves the strengthening or weakening of synaptic connections between neurons, this allows our brain to adapt to new information, experiences and also to compensate for lost connections after injury. We also have neurogenesis, which is the restoration of damaged tissue and some new neuron formation, particularly in response to injury. And lastly the most important process in my option is the remyelinationof nerves or myelin plasticity. Myelin protects our nerves and brain from the external environment of our body whether it’s bacterial toxins like lipopolysaccharides[†] ornon-native electromagnetic fields (nnEMF). Our myelin sheaths which insulate our nerve fibers act as a protective armor, facilities efficient transmission of communication signals between nerves and provides metabolic support to neurons. I believe this to be the most important process because “myelin which provides fast signal transmission, allows for synchronization of neuronal inputs, and helps to maintain neuronal function”^13A and is a widely supported component necessary for a new or existing network to function with “fast and effective propagation of action potentials.”¹⁶ It’s observed in neurodegenerative diseases such as Parkinson’s, Alzheimer’s or Multiple Sclerosis that demyelination lead’s to various neurological symptoms such as cognitive decline and motor skill dysfunction.

Circadian Biology and human health:

What if I told you that our bodies have a region in the brain that contains a “biological clock”^6A, a system that regulates our innate sense of time. The suprachiasmatic nucleus (SCN), houses the main clock of the brain, coordinating various daily rhythms in physiology and behavior. It receives direct input from the retina (in the eye), which helps synchronize it to the external light-dark cycle. It then sends signals to other brain regions and organs to regulate processes like the sleep-wake cycle, hormone release, healing and body temperature. According to a Harvard Medical School article, “At night, light throws the body’s biological clock—the circadian rhythm—out of whack. Sleep suffers. Worse, research shows that it may contribute to the causation of cancer, diabetes, heart disease, and obesity.”¹⁷ See the graphic in figure 3 to see lights effect on the SCN. Today we’re what I like to call the “indoor” generation. We live under artificial light, use these screens that emit toxic levels of blue light and are surrounded by technology constantly emitting doses of nnEMF. Now clinicians and researchers seem to be confused why we have this disease epidemic? Could it be we’re looking in the wrong places? It seems there’s a lack of funding for the study on the implication of artificial light, full spectrum lights healing properties and chronic exposure to nnEMF. Perhaps that’s intentional? I mean any breakthrough that disrupts the profits of a multi-billion-dollar industry would be avoided, right?

Artificial light at night or (ALAN), is extremely detrimental to our health. A main issue is with tricking our bodies it’s light out when it’s really dark out. It may be foreign to you but we have non-visual photoreceptors which are light-sensitive cells that detect light but are not involved in the process of sight. They play a crucial role in regulating various bodily functions, including circadian rhythms and hormonal release. You have a brain with consciousness to understand through your eyes that it’s dark out even if the light bulb is the source of light. Our non-visual photoreceptor system is not privy to that understanding and if it senses light, it chemically signals to the body its day time. So, you can see that artificial light past sundown over time can create dysregulation of our basic biological systems. Light has the ability to change the hormone panel we use based on its wavelength.

Artificial light coming from the LEDs in our screen technology mostly emit the blue light spectrum. With today’s current research, exposure to blue light is associated with the increased level of the stress hormone cortisol. As noted in a 2023 paper published in The National Library of Medicine, “bright lights of any colour during the late night or early morning can induce significant increases in cortisol secretion”¹⁸ Cortisol is one of the main hormones that drives us in the wake cycle in the morning, for reference our sunrise has ample blue light present and is stimulatory to waking us up. Even though we primarily see a red, orange or yellow hue, because as NASA confirms, “Blue is scattered more than other colors because it travels as shorter, smaller waves.”¹⁹  As the National Oceanic and Atmospheric Administration NOAA, further explains “If the path is long enough, all the blue and violet light gets redirected out of your line of sight, while much of the pink, orange, and red colors continue along the undeviated path between your eyes and the sun.”²⁰ With knowing this we should think about how light is affecting our biological systems. Naturally at night our body should be releasing the hormone melatonin to cause sleepiness. Instead, the blue light from our technology and artificial lighting in the evening is sending signals to our body to release cortisol instead of melatonin, confusing our systems and creating dysfunction.  

Light as a function of the circadian rhythm has by far the biggest influence on the 24-hour cycle. Light, as day and night are not only for releasing melatonin to cause sleepiness but light is a novel mechanism of communication between neurons and darkness is a major contributing factor. According to a 2022 article in the Neural Regeneration Research Journal,  

Nearly all neurons, particularly those of the central nervous system, are encased in bone (cranium and vertebral column) and thick connective tissue coverings (meninges). They work, for the most part, in near total-darkness. In these regions, communication by biophotons may be little influenced by external light. But there are some notable exceptions. The neurons of the retina, as well as peripheral sensory neurons innervating the skin are exposed continually to light and these neurons, unlike those that work in the dark, could have their biophoton network compromised. ²¹

As for the neurons in the retina that are exposed continuously to light, they are called the retinal ganglion cell (RGC). This cell has a protein called melanopsin that is light-sensitive and plays a crucial role in regulating non-image-forming visual functions, like the circadian rhythm, sleep-wake cycles and hormone secretion, particularly melatonin. Its presence is important because it directly responds to light and according to an article in the National Library of Medicine our eye has a, “peak response sensitivity in the blue spectrum.”²² Cells can emit blue light due to the creation of native endogenous biophotons, specifically to communicate their activity and homeostasis state. This is why non-native exogenous blue light mostly at night is so dangerous, it alters cellular communications at the base level of information transfer. Yes, you read that right the human cell creates its own light called ultra-weak photon emission or more recently called biophotons, to communicate. The Neural Regeneration Research Journal reports that, “neurons self-generate light across a range of wavelengths, from ultraviolet to red and near infrared;”²¹ In fact, all living cells produce this light signature although invisible to the naked eye, their existence has been confirmed through scientific measurements in various living organisms, including humans, animals, and plants. 

Another factor impacting our health and natural healing abilities is the constant source of non-native electromagnetic fields, (nnEMFs). These are electromagnetic fields that are produced by a non-native source. Think of our electronics, cell towers, satellites, WIFI routers, smartphones, computers, wireless Bluetooth devices, electric cars, even our electric grid. Biochemistry has taught us that electrons are fundamental to how our cells produce energy, signal, communicate and cell-cell interactions such as the negative charge on the surface of red blood cells (RBCs) preventing them from clumping together. As an article in the National Library of Medicine reports, “These charges help prevent the interaction between RBCs and the other cells and especially between each other.”²³ It is vital our cells maintain a negative charge and nnEMFs mess with exactly this by “stealing” electrons and reducing the number of free electrons available. This EMF is not compatible with our biology and causes confusion of what to do with frequencies like 5G, WIFI routers, smartphones, Bluetooth and our electric grid.

Imagine for a moment you go to charge your phone with the wrong charger a 200 watt rather than the typical 5-20 watt (the plug fits in this example, let’s assume they’re all universal), too large a charger will deliver too much power, create heat and permanently damage the battery.

This exact situation doesn’t happen to our body; however, a similar scenario can be applied to our bodies when we are exposed to nnEMFs. As bioelectromagnetism suggests humans are electromagnetic beings and our biology is designed to operate at certain electromagnetic frequencies that are not the ones, as an article in the Journal of Microscopy and Ultrastructure reports, “emitted by radar, communication equipment, mobile phone base stations, high voltage lines, radio and television transmitters, substations, and electrical equipment at home and work, in addition to many electrical systems in the environment.”²⁴ Each technology will utilize specific frequencies for its application.

The human biology doesn’t have instructions for these frequencies and it creates disruption and a dysregulated environment in our cell and some studies suggest even effects on the blood-brain barrier (BBB)[‡]. One strong hypothesis is from the thermal effects on the cell from long term exposure. Again, from the Journal of Microscopy and Ultrastructure itnotes, “Thermal effects are associated with the heat created by EMFs in a certain area … It is possible that every interaction between RF fields and living tissues causes an energy transfer resulting in a rise in temperature.”²⁴ Since we have no use for these frequencies, the energy from the nnEMF is absorbed by the cells and converted into heat since it can’t be used for anything else. If the stress is too severe or prolonged, the cellular response mechanisms may fail to resolve the situation, leading to cell damage or death over time. Stated in the same article, “Many studies have suggested that EMF may trigger the formation of reactive oxygen species in exposed cells.” ²⁴

Our bodies over time have developed defensive mechanisms to combat free radicals[§],  however,  

If these antioxidant defense mechanisms are impaired through exposure to an agent that causes the overproduction of ROS, including EMF, antioxidants may not be sufficient or free radical formation may increase to such an extent that it overpowers the defense capabilities of antioxidants. ²⁴

According to an article in The International Journal of Biomedical Science, on our bodies free radical defense capabilities,

When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. ²⁶   

Adding even more insult to injury from a 2011 paper by Nora Volkow, she demonstrates you can change metabolism with frequencies alone. In this paper the participants who had 50-minute cell phone exposure were associated with increased brain glucose metabolism in the region closest to the antenna.²⁸ In other words, by putting a cell phone up to the side of your head you increase blood glucose and insulin levels, no food needed. So, what does a constant exposure to a WIFI or 5G frequency do throughout the body?

Humans are resilient creatures so the effects won’t be felt overnight. But long-term exposure to them can be truly disastrous for our health especially combined with all of man’s other modern electronic innovations. We spoke about the harm modern food, supplements, artificial light and nnEMF can have on our body, not even mentioning modern agriculture processes, endocrine disruptors in our hygiene products, cleaning products and plastics we use on a daily basis. This all can seem very concerning, but what if I told you there’s a way to renovate our body daily to keep it healthy dispute all these factors. Welcome to sunlight, grounding and free electrons.

We get electrons from our sun, the earth, movement, food and just like our smartphone we need to recharge with electrons on a regular basis in order to have homeostasis. Sunlight also has what’s called full spectrum light, remember the acronym ROY-G-BIV, red, orange, yellow, green, blue, indigo and violet. In turns out each color has a corresponding wavelength that signals to our biology a specific hormonal process. It’s such a finely tuned system that it follows the light-dark cycles of our cyclical environment. Think sunrise, sunset and over the course of the year, we have various seasons based on the suns cadence. This is the reason why we need to align ourselves with the earth’s biological rhythm, the circadian rhythm, it’s the Earth’s 24-hour cycle of day and night. We know the importance of lights role influencing sleep-wake cycles, hormone release, and other physiological processes. With today’s scientific instruments like the photomultiplier[**], we can measure most lights specific wavelengths and its corresponding effect on biological organisms.

For healing renovation purposes, the red and near-infrared (NIR) wavelengths are king. Keep in mind all wavelengths play a very important role in signaling biological systems and it’s extremely important to understand that everything in nature experiences full spectrum light, even the food we eat. Nowhere in nature can we find an isolated wavelength. Now that we know some of the harmful effects on our biological system, it then poses an interesting question when we look at study’s done on diet, exercise and medicine. It seems all studies are done at an indoor lab, where the only light control we can infer is they’re all conducted under artificial light. Then the results are reported as key findings to help public health, yet, this contradicts everything biology experiences in natures natural environment. 

Morning Sunlight:

A practice you may have heard before is to expose your body to early morning light, specifically at sunrise. The reason for this is that at sunrise the shorter wavelengths, most notably the blue end of the visible spectrum is scattered away by molecules in the atmosphere, this is through a phenonium called Rayleigh scattering.[††] This observable absence of the blue end of the visible spectrum allows for the longer red wavelengths to saturate the sky and penetrate down to the observer. For this brief window of time the sole presence of red, orange and yellow wavelengths can be used to renovate our bodies in many ways. As discussed in a Scientific Reports 2025 article, “Long wavelength red light that can extend beyond the human visual range penetrates deeply through biological tissue. Exposure to these longer wavelengths improves mitochondrial function and ATP production.”²⁹ It is well documented that the long red wavelength is beneficial to stimulate healing, relieve pain, and reduce inflammation. A prominent mechanism being an increase in adenosine triphosphate (ATP) production — the energy currency of the body, leading to an improvement of the cell’s ability to fight infections and accelerate healing.

The light present at sunrise initially has no ultraviolet A (UVA) or ultraviolet B (UVB) present, this makes for an excellent environment to expose our bare skin for the red light to pernitrate deep into our tissues and renovate our cells. There are many specific biological processes that are benefited from red light exposure, from the perspective of healing a brain injury or preventative care for neurological diseases, I’m going discuss how red light on hemoglobin proteins start us in the maintenance process to remyelinate. As I’ve previously said, myelin is a widely supported component necessary for new or existing networks to function optimally and if the brain network is damaged in anyway it can lead to various neurological symptoms.

Hemoglobin (heme), is a protein in red blood cells responsible for oxygen transport, it cannot transport oxygen in a Fe³⁺ state. Blue light (430nm) shifts Fe⁺² to Fe⁺³ via oxidative stress, as demonstrated in this 2025 study in Cellular & Molecular letters, “Exposure of A2E to blue light promoted ferroptotic cell death in RPE cells by elevating ferrous ion (Fe²⁺) levels.”³¹ Now when we look at red light in the spectrum (~500-700nm) it shows effective to reduce Fe⁺³ to Fe⁺², while this photoreduction process is not taught in the centralized world of science it is supported in the Journal of Photochemistry and Photobiology, “… it was known that Fe³⁺-aqua complex can be reduced to Fe²⁺ under UV–vis irradiation (λ < 580 nm).”³² The Fe⁺²/Fe⁺³ redox cycle at sunrise can be considered a photoreduction process whose mechanism functions to reduce the state of Fe⁺³ heme to Fe⁺². Morning sunlight has the highest quality of red light to constantly renovate every single heme protein so it can carry oxygen most efficiently. As we consider what we’ve previously discussed on blue lights effect on human biology, coupled with its ability to shift Fe⁺² to Fe⁺³ via oxidative stress, we can see the importance of prioritizing sunrise for the red renovating wavelengths. I learned to research this idea by following the work of a neurosurgeon by the name of Dr. Jack Kruse[‡‡].

The brain which receives about 20% of the total cardiac output despite only making up about 2% of total body weight, make’s implementing novel ways to direct oxygen more efficiently to the brain important for overall brain health. Identified in the Journal Life, “These processes require energy (in the form of ATP) and building blocks for lipids and proteins, which implies a tremendous investment of energy fuels.”³³ Oxygen is vital ingredient for mitochondria within neurons to generate the energy required (ATP) for myelination and myelin maintenance through oligodendrocytes (OL[§§].) As a 2022 article in Cell Neuroscience emphasizes, “Given the critical role that energy production plays in proper OL function and overall brain energy demand, it is important to understand the underlying metabolic components at work … and how they may be used to counter … demyelinating diseases.”³⁴

The Journal of Cell Science maintains that, “In humans, around 40% of the brain contains white matter comprising densely packed fibres, of which myelin is a main component (50–60% dry weight of the white matter.)”³⁵ With these figures we can attest that our brains are composed of 20% myelin by volume, the large percentage suggesting a vitally important need for healthy brain functioning. Most of the environmental damage to our myelin can be primarily mitigated by maintaining and supporting a prime light environment to assist in remyelination and myelin maintenance.

During early morning sunlight, the most prominent wavelengths are red & IR light, and with those it stimulates filaggrin & urocanic acid production. Filaggrin is a vital protein that supports a healthy skin barrier, regulates skin pH, and protects against environmental factors by reducing the penetration of allergens, irritants, and ultraviolet (UV) radiation into the skin. Urocanic acid (UCA) is a molecule that occurs naturally in the skin, liver, and brain, and is involved in a number of processes related to skin health and disease. Most notably is its role in immune system support, skin barrier protection by acidification[***] of the skin’s surface and UV protection by absorbing UV radiation, particularly UVB, and acting as a natural sunscreen. It’s important to know that filaggrin is a major source of histidine[†††], which is then converted to UCA in the stratum corneum (outer most layer) of the skin. So, we can see the early morning sun not only renovates but prepares our body for midday sun which contains UV radiation and is necessary for vitamin D synthesis.

Midday Sunlight:

This spectrum of light now consists of the shorter wavelengths, such as green, blue, indigo and violet completing the spectrum and allowing for the beautiful vivid color we experience. Midday sun also consists of UV radiation which is fundamentally necessary for endogenously made vitamin D. UV has a bad reputation in our medical field because of its ability to damage DNA and create health issues. As I refer to the benefits of UV light, I’m including the knowledge of filaggrin and urocanic acid productions protective UV benefits as well as the role melanin plays as a natural sunscreen shielding our body from the harmful UV rays. Melanin absorbs and disperses UV radiation from the sun. When our skin is exposed to UV rays, melanocytes (specialized cells in the skin) produce melanin and distribute it to nearby skin cells. It’s a dynamic balance where UV rays can damage the body but also allow for melanocytes to produce melanin for protection and synthesize vitamin D. With a proper understanding of UV light, we can harness its benefits.  As humans we have three types of melanin eumelanin, pheomelanin, and neuromelanin. They’re responsible for the pigments in our hair, eyes, skin color and can be easily recognizable as the change in skin color as we get a tan, then there’s melanin in our brain as Neuromelanin.

One of the most recognized benefits of UV light is its ability to synthesize Vitamin D in the body. Unlike other essential vitamins, which must be obtained from food, vitamin D can be synthesized in the skin through a photosynthetic reaction triggered by exposure to UVB light. Vitamin D is actually a hormone rather than a vitamin. Vitamin D is mostly produced in the skin in response to sunlight and a small amount of a healthy balanced diet. The liver and kidneys convert vitamin D (produced in the skin and taken up in the diet), into the active hormone, which is called calcitriol (1,25-dihydroxyvitamin D).

In the green medicine world, we have created a synthetic form of Vitamin D as a supplement. From a podcast with Dr. Alexander Wunsch³⁷ who’s a physician in Germany for holistic medicine and photobiology a question arises, Is the sun better or vitamin D supplements, or does it not make a difference? He concludes, the specialists did not find a consensus. He goes on to explain that if you ingest the 25 hydroxy vitamin D, then it will be transported not only by the D binding protein, but it will also be transported by lipoproteins. Yes, the same LDL that’s seen in our blood panel. The supplement shows a different distribution panel in your body because it’s not mainly bound to the D binding protein, but also to the standard lipoprotein molecules. This means that it might not reach the same cell types if it’s bound to one or the other. This transport process doesn’t bind Vitamin D specifically and cannot transport it to target receptors in the same way the specific binding protein does via a photosynthetic reaction form of vitamin D creation, through the use of a D-Binding protein. In the words of Dr. Alexander Wunsch, Lipoprotein delivery is like “Unaddressed mail”, it has no specific delivery address and does not arrive safely where it is needed. Where D-binding protein is like “Registered mail,” a preferred transport arriving safely to the addressee.

 It becomes apparent that we can support a case for routinely healthy exposure to UV light. However, you have to sun bathe responsibly by covering your skin or going into the shade when you feel it burning, plus building a tan to protect yourself. Taken from a technical report of the CIE (International Commission on Illumination) “Based on a review of the evidence of both the beneficial and the harmful effects of solar exposures it is concluded that people should not shun the sun, even not at noon.”³⁸ If you go directly out in the sun with no “solar callus” which is you’re tan, you’ll burn from prolonged exposure. I hope you wouldn’t lift weights until your hands bleed from no callas; you’d probably grab some gloves or stop when you felt tears against your skin. But as you may have experienced, you’ll no longer need gloves after a while as you develop calluses. The same is true with your skin and sun exposure; ease into it as you would with the calluses on your hands.  

Near-infrared radiation (NIR):

This wavelength is always present during daylight hours; however, its intensity fluctuates. In today’s analysis, NIR makes up the largest portion in the spectrum of sunlight, with around 52%-55%, while visible light is around 42%-43% and Ultra Violet (UV) is at roughly 3%-5%.³⁹ NIR is generally higher as a total percentage at sunrise and sunset with a longer wavelength then even red light, midday light has higher levels of visible light the shorter end of the wavelengths. According to an article by the University of Wisconsin–Madison “sunlight passes through more air at sunset and sunrise than during the day, when the sun is higher in the sky. More atmosphere means more molecules to scatter the violet and blue light away from your eyes.”⁴⁰ The NIR wavelength has the deepest penetration depth of all the solar spectrum wavelengths with the ability to penetrate through clothing, bone, and into the brain and cerebrospinal fluid. It’s able to get deep into the tissues and cells specifically into the mitochondria. Current research suggests this light is absorbed by mitochondrial chromophores[‡‡‡] like cytochrome c oxidase, leading to increased adenosine triphosphate (ATP) production and improved cellular respiration.⁴¹ ATP is known as the energy currency of the cell because it is the primary molecule used to store and transfer energy within cells. Scientists like to say, it acts like a rechargeable battery, storing energy when produced and releasing it to power cellular processes. ⁴² This can result in various health benefits, including faster healing, reduced inflammation, and improved cellular energy metabolism. 

It’s becoming more known and apparent that melatonin is not exclusive of the pineal gland but mostly produced in the mitochondria with a strong antioxidant effect. Research in a 2024 article tells us, pineal melatonin was found to be less than 5% of the synthesized melatonin in the body. “Extrapineal melatonin synthesis does not exhibit a circadian rhythm and it is not released into the blood as pineal melatonin does but acts locally in its cell of origin and possibly in a paracrine matter on adjacent cells.”⁴⁴ The biggest story of NIRs health benefit is the increased production of ATP at the mitochondria level in the cell. This can influence the chemical production of extrapineal melatonin which evidence shows is made in the mitochondria. This extrapineal melatonin acts as an antioxidant by donating electrons to neutralize free radicals and reactive oxygen species (ROS).⁴⁴ Today’s research shows, “melatonin production and the beneficial effects of sun baths or photobiomodulation therapy may be, at least, partially mediated by the increased local melatonin production induced by NIR.”⁴⁵

The melatonin that’s not made in our pineal gland, which accounts for most made in our body, at roughly 95%, is shaping up to be this powerful endogenously made antioxidant. According to the Biology 2023 article, “Throughout the history of melatonin research, almost exclusively, the focus has been on nocturnally-generated pineal melatonin production.”⁴⁵ This finding about melatonin gives us a peek on how we can purposely renovate our bodies. We have research showing its ability to stimulate the production and activity of enzymes which play crucial roles in neutralizing free radicals. It directly interacts with and neutralizes harmful free radicals by donating electrons to these unstable molecules, stabilizing them and preventing them from causing further damage. Melatonin is effective in preventing damage to mitochondrial DNA and proteins whose protection is vital for maintaining proper ATP synthesis, the cell’s energy source. Now with the evidence and research of extrapineal melatonin acting as a powerful antioxidant we can see how the body truly can renovate itself given an optimal environment.

What’s not widely known but may seem obvious now that you’ve read it, plants primarily reflect NIR light rather than absorbing it. Try touching a leaf on a hot sunny day, it’s cool. This is because the pigments like chlorophyll, which are essential for photosynthesis, are not sensitive to NIR photons and reflect them. This gives us multiples of normally obtained NIR and a reason to get outside in nature as much as possible whether in the sun or shade. Light has immense benefits and can be considered the free decentralized pharmacy for our health.

Grounding / free electrons:

Grounding is the act of reconnecting with the Earth’s natural electrical current. Emerging science is showing us that this simple act of connecting with the Earth’s surface, may just provide us with one of nature’s most abundant sources of antioxidants. The Earth’s surface is an electron reservoir of free electrons just waiting for us to tap into. Our skin is naturally conductive so we can easily absorb these free electrons and they can be quickly utilized in the body. An Inflammatory process is created by oxidative stress or free radicals. See figure 4 for an overview of environmental free radical sources. According to the book, Neurobiology of Brain Disorders, if a molecule has unpaired electrons in their outer shells, it makes them highly reactive and unstable.⁴⁶ Identified in an article of the International Journal of Biomedical Science, these unstable molecules will “steal” electrons from other molecules to complete their outer shells and achieve stability. This stealing can create a chain reaction whereas the newly formed free radical is now unstable and looking to regain stability by taking an electron from another molecule. This chain reaction can damage important cellular components like proteins and lipids, disrupting their normal functions and ultimately leading to DNA cellular damage. If we continue to have an excessive formation of free radicals the resulting damage is known as oxidative stress.⁴⁷ 

A second form of oxidative stress can be created by Reactive Oxygen Species (ROS). According to current research they are produced during normal cellular processes, particularly in mitochondria during energy production as well as external factors such as UV radiation, nnEMF, pollutants, and toxins.^48,49 Partially in nnEMF, it is strongly hypothesized the artificially created frequencies can cause electrons to “leak” from the electron transport chain (ETC) in the mitochondria, resulting in excessive ROS generation. This concept that nnEMF exposure can create oxidative stress through mitochondrial dysfunction is supported by numerous experimental studies.⁵⁰ However, the specific mechanisms and overall consensus remain a subject of ongoing research.

We have the ability to neutralize ROS in a healthy balanced state, according to a recent article in the Journal Antioxidants, it acknowledges that,

Cells possess a robust antioxidant defense system in the cytoplasm and cellular organelles, comprising enzymatic and non-enzymatic antioxidants that synergize ROS and uphold redox balance. Essential enzymatic antioxidants include SOD, catalase, glutathione peroxidase, and glutathione reductase. Non-enzymatic antioxidants include molecules like glutathione (GSH), ubiquinone (coenzyme Q10), vitamins C and E, alpha-lipoic acid, and thioredoxins. These antioxidants counteract excess ROS, mitigating oxidative stress and preserving cellular redox homeostasis. Imbalances that favor ROS over antioxidant capacity can trigger oxidative damage, initiating pathological pathways associated with various diseases.⁵¹ 

If our ability to neutralize these reactive molecules gets overwhelmed and the innate ability to maintain redox homeostasis is in excess of the typical cellular metabolism and crucial processes, we get inflammation. If this state persists it can lead to chronic inflammation, a prolonged state of inflammation that can contribute to the development of various diseases. Here’s some great news, remember I told you earth is a reservoir of free electrons. Well, we can absorb these free electrons and they can be utilized in the body to help stabilize these reactive molecules. According to an Environmental Protection Agency (EPA) study, Americans spend 90% of their time indoors.⁵² This includes time spent at home, work, and in transit, with a significant portion of that time in buildings and vehicles. It should be apparent by now that the indoor environment we exist in is detrimental to our health. This information is why I focus on the importance of responsible sunlight, grounding and free electrons over the centralized medical system dogma.

Conclusion:

Align to a natural circadian rhythm 24-hour cycle. Prioritize the sunrise, with the most skin exposed as possible, obtain a plentiful amount of naturally made endogenous Vitamin D through responsible sunbathing. Limit toxic blue light after dark and before bed. Practice grounding to create a better environment for your body’s natural repair processes. These practices are very specific and I agree not always coinvent, but if you live with a brain injury and aliments as I do, healing and the prevention of future major hemorrhages should be a priority. I am determined to heal way beyond the centralized medicine accepted scope and I hope you are too. My research stems deep into the decentralized literature on light, nnEMF, quantum and circadian biology. These views are very unconventional as doctors in the centralized system are not taught these ideas. With time and research these ideas will make more sense and many connections to other diseases will be made as well.    

Personal Protocol: For prevention and healing renovation

• Rise to see the sunrise with the most skin exposed as possible, temperature permitting. Ground at the same time as sunbathing, you can ground as long as the surface you’re on is solid and connected to the earth. Sitting on a metal chair or on a wood deck will not work.
• Sunbathe in midday sun to naturally make endogenous Vitamin D, I look to get a 7k IU dose when sunbathing. You can track your UV Index, IUs generated and Vitamin D levels based on your geographic location in many app’s. According to The Journal of Clinical Endocrinology & Metabolism, our body can store 25-hydroxyvitamin D [25(OH)D] the precursor to Vitamin D, mainly in adipose tissue otherwise known as fat. While 25(OH)D is stored in fat, it can also be released back into the bloodstream. This release is thought to help maintain serum 25(OH)D levels, particularly during periods when vitamin D production is low, such as winter.^16B 
• At dusk I look to cut artificial light to a minimum and use redlight bulbs in our bedroom and bathroom as well as a redlight nightlight. I try not to use any screens before bed.

Afterthought:

I would like this word “somatic reversion” to live in the daily consciousness of your thoughts. In an article from The American Society of Hematology, it states,

Somatic reversion is the acquired alteration of inherited pathogenic mutation, resulting in the partial or full functional recovery of the affected protein. It has been reported in many inherited genetic disorders, and potential mechanisms have been reported as back mutation, intragenic recombination, second site mutations suppressing the effect of the original mutation, frame-restoring second site insertions, and deletions.^17B

This process involves a spontaneous correction and if the correction gives the reverted cell a selective growth advantage, it can outcompete the surrounding mutated cells to produce a batch of healthy cells. There is a way that our bodies can reverse lesion formation and heal from disease, we’ve seen CCM lesions shrink perhaps this mechanism had a role. This is highly speculative but has a non-zero chance of being possible. It’s important to understand the study of Epigenetics and how it refers to how our behaviors and environment can cause changes that affect the way our genes work. Consider it a “switchboard” for our genes, we experience factors from our environment and lifestyle like diet, exercise and chemical exposure from pesticides and smoke to stress, strongly held beliefs weather helpful or hurtful or even social experiences which all can impact our gene’s expression.

The familial CCM mutation can lead to lesions located in the vascular system. In the textbook Molecular Biology of The Cell, it reports,

In most adult tissues, endothelial cells turn over very slowly, with a cell lifetime ranging, for a mouse, from a couple of months (in liver and lung) to years (in brain and muscle). But endothelial cells not only repair and renew the lining of established blood vessels, they also create new blood vessels. They must do this in embryonic tissues to keep pace with growth, in normal adult tissues to support recurrent cycles of remodeling and reconstruction (as, for example, in the lining of the uterus during the menstrual cycle), and in damaged adult tissues to support repair. In such circumstances, they can be roused to proliferate with a doubling time of just a few days.^18B 

In the human body the endothelial cells line the capillaries where the CCM lesion form. My intention here is to share the scientific process the body undergoes in replacing the mutated cells weather from normal turnover or after an injury like a hemorrhage. These cells don’t have a lifetime lifespan with us, well get multiple opportunities for somatic reversion.

I believe that the more specific information you put into your conscious mind about healing and the more understanding you have of how the body works, you’ll raise the bar of what’s possible, increase your perspective, grow your belief and allow yourself to achieve “supernatural healing.” The body has the ability to heal itself in miraculous ways.

For further reading on specific topics such as diet, sunlight and grounding check out these blogs

Eating for you gut health.

Sunlight, it’s reach into Human Biology.

Inflammation, Antioxidant-Grounding 101.

Keep the faith,

The entire contents of this blog are based upon the opinions of Corey Diggins, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this blog is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Corey Diggins. Corey Diggins encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.

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(F3) Circadian rhythm the SCN and lights effect. Image Source: Retrieved November 19th, 2025. from, https://lightawake.biz/science-of-waking-up/

(F4) Environmental free radical causes. Image Source: Retrieved November 19th, 2025. from, https://solesence.com/what-are-free-radicals-anyway/.

[*] An “immunohistochemical” technique is used in biomedical research to detect specific antigens (proteins) in a tissue sample, helping to visualize their location and presence at a cellular level.

[†]  Lipopolysaccharides (LPS), are part of bacterial cells walls and are released when the cell dies. They are safely contained in a healthy gut but become toxic when a compromised gut barrier allows them in the bloodstream triggering a inflammatory response in the immune system.

[‡] The blood-brain barrier is a selective semi-permeable layer of cells that defend your brain from harmful substances, germs and other things that could cause damage. Recent studies now suggest that these nnEMF frequencies “may trigger several neuronal disorders.” ^24,25 

[§] Free radicals are produced by a variety of normal biological processes including aerobic metabolism and pathogenic defense mechanisms. They can also be a result of external exposures such as radiation, pollutants, and cigarette smoke. Reactive oxygen species, or ROS, are a subset of free radicals that contain oxygen. ²⁷

[**] Photomultipliers are used to measure any process which directly or indirectly emits light. They can detect light in the ultraviolet, visible, and near-infrared ranges of the electromagnetic spectrum.

[††] The term Rayleigh scattering is named after British physicist Lord Rayleigh, who established a mathematical formula in the 19th century to describe the scattering process. As sunlight travels through the atmosphere, it interacts with nitrogen and oxygen molecules, causing shorter blue wavelengths to diffuse and create the blue sky we observe. During sunrise and sunset, when the Sun is lower in the sky, its light encounters a greater thickness of the atmosphere, scattering the shorter wavelengths and allowing the longer red and orange wavelengths to dominate, resulting in the warm hues often seen during those times.³⁰

[‡‡] The idea to research that sunrise can provide an environment for a Fe⁺²/Fe⁺³ redox cycle to occur was spurred on by Dr. Jack Kruse on Dr. Brandon Crawford’s podcast.³⁶

[§§] Oligodendrocytes are the myelinating cells of the central nervous system (CNS.)

[***] Acidification functions as a defense mechanism controlling the growth of undesirable microorganisms.

[†††] Histidine is an essential amino acid that is used in the biosynthesis of proteins and a precursor for several hormones.

[‡‡‡] According to researchers a chromophore is a portion of the cell responsible for absorbing light wavelengths to create a biological effect.⁴³